Which local waters do you feel are "safe" to eat from?

Lake Arthur
Pymie
Erie
Wilhelm
Pretty much any lake.
 
I know people who eat from the 3 rivers and I'm not so sure I'd be comfortable doing it unless it was upper, upper Allegheny past Kittanning.
 
I would not worry about a few meals here or there from pretty much anywhere.

It's all in your comfort levels, if you read the consumption advisories and are still not comfortable eating it, or question whether or not it's safe, then don't eat it. Just think, do you think the fish you buy from the store is advisory free? I highly doubt it. Like I said, I wouldn't recommend daily consumption of fish, but a meal once or twice a month isn't going to harm you IMO.

Esox_Hunter

You would be hard pressed to find any waterways in this state that don't have mercury and/or PCBs in them.  

People are scared to eat fish from the 3-Rivers mainly because of the sewage overflows.  That is bacteria and as long as the fish is cooked properly, the bacteria is harmless.  I still only eat a meal or two of walleye a year from there, which are typically the smaller males.  Females go back to swim another day, but not for safety concerns, I just like to do my part to ensure that they are not overharvested.

What it boils down to is that moderation is the key for both safety reasons and preservation of the fishery.    

I'm not suggesting that I'd eat tons and tons of fish even if they were safe, just for clarity. I agree that we need to stay responsible about what we keep for the sake of maintaining a healthy population. 
 
I myself have never caught a legal walleye from the rivers (I've been fishing around here for a very long time, but like I said in another post, never consistently enough to really really learn and master techniques or to learn enough information to get as good as most of you guys, some years I havent gone fishing at all, other years maybe 4 or 5 times in a year. This year I'm going every chance I get and Ive been out a TON in '13) but if I did, I would probably release it anyway out of both concern for safety and to keep the population healthy. 
 
Smallies, I wouldnt worry near so much if they were safe because there are just SO many of them. 
 
I guess what prompted the question though is that I'd like to feel confident in taking home more than the very very rare pellethead. North park lake or twin lakes, say I catch a nice channel cat, I wouldnt quite know if I was safe eating it, but I'd love to take one home since I find catfish to be delicious. Heck even Panther Hollow Lake which is literally on my way home from work has plenty of fish in it. But I have no idea what the source of the water is or how clean it is. 
 
Just trying to get educated, Im getting a lot more serious about fishing this year and it's time I really knew what I was doing and I'd love fry a few up every now and then. 
 
Appreciate all the feedback!