Nothing like fishing the rivers and creeks of PA. during late summer/early fall. French Creek is my go to water for this time of the year but, the Allegheny is never out of the question. Regardless of the water, I target the tailout of the slower moving eddies especially where a narrow trough exist. The trough is where I want my bait to end up no matter what the bait. I work the area from different angles throwing surface baits, spinners, and jigs. Rapalas (of course) are my surface lures followed by CP Swings (a fantastic all around spinner) and then the jigs (tipped with 'twister tails').
Water clarity will dictate my choice in spinner flash as well as my choice in twister tails (the clearer the water; the darker the bait). The surface baits are chosen by both the water clarity and color of the sky. ie. Clear water under a sky having white clouds will call for a smaller bait having a white (or light colored) belly.
I also consider the time of day when choosing which bait to try first and how long I spend at a given area.
However, given the choice of having only one bait, that choice will be the jig and twister tail. A quarter ounce tipped with a black two and half inch 'tail'. You can swim it at various depths, you can bounce it on the bottom (risky) or, you can drag it (even riskier). Short of having the exact bait, the 'tails' mimic leeches and/or helgramites.
Plan on losing some jigs but, thats the price to pay.
One other thing, I fish using no more then eight pound test line.
Hope you find something here useful and happy fishing. Remember, a bad day fishing still beats a great day at work.